Hamilton police said it happened shortly after 2 a.m. on Upper Wentworth Street, between Kingfisher Drive and Lincoln Alexander Parkway.
A passerby found the pedestrian and immediately called 911. Emergency crews responded and rescuers rushed him to the hospital in critical condition.
Police said the man was hit by a southbound vehicle that fled the scene.
“Due to the serious injury he sustained, the Hamilton Police Service’s Collision Reconstruction Unit was activated and is continuing its investigation,” police said in a statement. “The road has reopened and police are investigating the area for witnesses and video surveillance.”
Investigators are asking anyone in the area who has plans or information about the incident to call the police or Crime Stoppers.
The incident comes a few days after another episode in Hamilton cost the life of the famous Canadian conductor Boris Brot.